形势喜人

读文献的46年来，以前是很少中国的论文，2000年后逐渐有，2015年以来可以见到的中国文章越来越多，但有很多跟风、还有不少垃圾。

不过，也有领先世界的。最近阅读的里面就有：

3、4是耳聋的基因治疗第三篇文章，这个领域第一篇是中国的，复旦附属眼耳鼻喉科医院和东南大学在多种耳聋基因治疗是领先世界。

8也是中国的进展

1. Hao L, Midorikawa T, Ogasawara Y, et al. (2026). Reversible one-way lipid transfer at ER-autophagosome membrane contact sites via Atg2. Journal of Cell Biology225:e202506039.

2. Sun J, Atiş IS, Empke SLL, Khokha MK, Breslow DK.(2026).A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology. Developmental Cell61:687–705.e9.

3. Van de Heyning P, Van Rompaey V. (2026). Gene Therapy to Treat Profound Hearing Loss. New England Journal of Medicine394:1126–1130.  

4. Valayannopoulos V, Bance M, Carvalho DS, et al. (2026). DB-OTO Gene Therapy for Inherited Deafness. New England Journal of Medicine394:1074–1083.

5. Sutton A, Alberts C, Xuan A, Minter N, Sanft A,et al. (2026). The Cell and Gene Therapy Access Model - A Vision for Future Development. New England Journal of Medicine394:1046–1048.

6. MinC, Ezenwanne C, DanceY, et al. (2026). Monocytes are biological sensors of aging and frailty in humans.bioRxiv 2026.03.10.710601.

7.Toro-TapiaG,BurbidgeH, BigaV, et al. (2026).Ciliary cAMP regulates Shh signal interpretation to drive polarisation of differentiating neurons.bioRxiv 2026.03.11.711079.

8. TaoY, Chu C, ChengZ, et al. (2026).Invivo-directed evolution identifies AAV-WM04as a next-generation vector for potent and durable hearing restoration in DFNB9.bioRxiv 2026.03.11.710960.

9. VangelatouM, StenboltkK, BayS, et al. (2026).An optonanobody for reversible photoactivation of recombinant and native α7 nicotinic. bioRxiv 2026.03.10.710770.

10. ZanderigoEJ, FatimaM, BeckerS, O'NeilAL.(2026).Alzheimer's Disease Brain Organoids as a Source of Disease Relevant Amyloid-Beta Oligomers. bioRxiv2026.03.09.710594.

11. Y Zeng, X Hu, Z Hu, et al. (2026).Instantaneous Beta Frequency Regulates Self-Generated Timing in Humans.bioRxiv2026.03.10.710730.

12. Zheng C, Hervé B, Meijer M, et al. (2025). Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis. Nature Neuroscience28:2612–2627.

13. Smith BA, Meeks CB, Murray-Brown I, et al. (2025). Balancing brain exposure, pharmacokinetics and safety of transferrin receptor antibodies for delivery of neuro-therapeutics. mAbs17:2592422.

14. Arafa D, van de Korput J, Braaker PN, et al. (2026). Myelin sheaths in the central nervous system can withstand damage and dynamically remodel. Science 391:eadr4661.

15. Monroe KM, Hong S, Lewcock JW, Yang AC. (2026). Therapeutic targeting of neuroimmune mechanisms in neurodegeneration. Nat Rev Drug Discov. 10.1038/s41573-025-01370-7. Advance online publication.

16. Boivin M, Yu J, Eura N, et al. (2026). GGC repeat expansions within new open reading frames are translated into toxic polyglycine proteins in oculopharyngodistal myopathy. Nature Genetics 58:517–529.

17. Everall A, Tapinos A, Hawari A, et al. (2026). Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types. Nature Genetics 58:570–581.

18. Chan ICC, Zhang P, Pan X, et al. (2026). CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis. Nature Genetics 58:582–592.

19. Nordmann GC, Balay SD, Kapuruge TN, et al.  (2026). A global screen for magnetically induced neuronal activity in the pigeon brain. Science 391:1155–1160. 

20. Delaveris CS, Loudermilk RP, Pandey A, et al. (2026). Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer. Science  391:eaec1778. 

21. Maher C, Saez I, Radulescu A. Decoding Covert Human Attention in Multidimensional Environments. bioRxiv 2026.03.11.710688.

22. PV Cherian, I Aviram, U Weill, et al. (2026). Trans-regenerational RNAi Memory in Planarians. bioRxiv 2026.03.11.711021.

23. Visconti di Oleggio Castello M, Guo J, Ma F, et al. (2026). Hyperface: a naturalistic fMRI dataset for investigating human face processing. bioRxiv 2026.03.11.711073.

24. Mary Louise Cramb K, Noor H, Thomas-Wright I, et al. (2026). Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading. bioRxiv 2026.03.11.711038.

25. Chauvin RJ, Zheng A, Metoki A, et al. (2026). Brain organization of a memory champion. bioRxiv 2026.01.11.698919.

26. Carlson RJ, Taiber S, Rubinstein JT. (2025). Gene Therapy for Hearing Loss: Which Genes Next?. Otology & Neurotology 46:239–247.

27. Du S, Ou F, Drieu A, et al. (2026). Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. Neuron, S0896-6273(26)00057-7. Advance online publication. 

28. Godugu D, Gattu K, Suri P, Daartey AB, Jadhav K, Rojekar S. (2025). Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches. Antibodies 15:1.

DB-OTO Gene Therapy for Inherited Deafness

V. Valayannopoulos and Others

N Engl J Med 2026;394:1074-1083 | Published Online October 12, 2025

The Cell and Gene Therapy Access Model — A Vision for Future Development

A. Sutton and Others

N Engl J Med 2026;394:1046-1048 | Published Online March 7, 2026

Monocytes are biological sensors of aging and frailty in humans

Chanhong Min, Charles Ezenwanne, Yoseph Dance, Nicolas Macaluso, Ladaisha Thompson, Lolita Nidadavolu, Akhil Katuri, Crystal Szczesny, Jacqueline Langdon, Edward Pearce, Peter Abadir, Jeremy Walston, and Jude Marvin Phillip

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.10.710601

 [Abstract] [PDF]

Ciliary cAMP regulates Shh signal interpretation to drive polarisation of differentiating neurons

Gabriela Toro-Tapia, Holly Burbidge, Veronica Biga, John Robert Davis, and Raman Das

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.11.711079

 [Abstract] [PDF]

In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and durable hearing restoration in DFNB9

Yong Tao, Cenfeng Chu, Zhenzhe Cheng, Yilin Sun, Ying Chen, Huifang Zhang, Shuyue Bao, Boyu yang, Baoyi Feng, Xianyu Huang, Yao Lu, Qiuxiang Yang, Xuegao Mao, Qifang Zhou, Chenxi Jin, Zhuo Duan, Guisheng Zhong, and Hao Wu

bioRxiv posted 11 March 2026 doi:10.64898/2026.03.11.710960

 [Abstract] [PDF]

An optonanobody for reversible photoactivation of recombinant and native α7 nicotinic

Maria Vangelatou, Kian Stenboltk, Sylvie Bay, Karima Medjebeur, Gabriel Ayme, Pierre Lafaye, arnaud Blondel, Alexandre Mourot, and Pierre-Jean Corringer

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.10.710770

 [Abstract] [PDF]

Alzheimer's Disease Brain Organoids as a Source of Disease Relevant Amyloid-Beta Oligomers

Eric John Zanderigo, Manaal Fatima, Sandy Becker, and Alison Linsley O'Neil

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.09.710594

 [Abstract] [PDF]

Instantaneous Beta Frequency Regulates Self-Generated Timing in Humans

Yitong Zeng, Xiangshu Hu, Zhenyi Hu, Jia Li, Qianyi Wu, Lu Shen, and Biao Han

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.10.710730

 [Abstract] [PDF]

GREGORY C.NORDMANNHTTPS://ORCID.ORG/0000-0001-8840-7777,SPENCER D.BALAYHTTPS://ORCID.ORG/0000-0001-7322-2825,THAMARI N.KAPURUGEHTTPS://ORCID.ORG/0009-0008-2402-9189,MARCONUMI,CHRISTOPHLEEBHTTPS://ORCID.ORG/0000-0002-7727-6246,SIMONNIMPF,E. PASCALMALKEMPERHTTPS://ORCID.ORG/0000-0003-1099-0119,LUKASLANDLERHTTPS://ORCID.ORG/0000-0002-5638-7924, ANDDAVID A.KEAYSHTTPS://ORCID.ORG/0000-0002-8343-8002Authors Info & Affiliations

SCIENCE

20 Nov 2025

Vol391,Issue6790

pp.1155-1160

DOI: 10.1126/science.aea6425

Decoding Covert Human Attention in Multidimensional Environments

Christina Maher, Ignacio Saez, and Angela Radulescu

bioRxiv posted 12 March 2026 doi:10.64898/2026.03.11.710688

 [Abstract] [PDF]

Trans-regenerational RNAi Memory in Planarians

Prakash V. Cherian, Idit Aviram, Uri Weill, Tamar Shapira, Sarit Anava, Hila Gingold, Jochen C. Rink, Oded Rechavi, and Omri Wurtzel

bioRxiv posted 13 March 2026 doi:10.64898/2026.03.11.711021

 [Abstract] [PDF]

Hyperface: a naturalistic fMRI dataset for investigating human face processing

Matteo Visconti di Oleggio Castello, Guo Jiahui, Ma Feilong, Manon de Villemejane, James V. Haxby, and Maria Ida Gobbini

bioRxiv posted 13 March 2026 doi:10.64898/2026.03.11.711073

 [Abstract] [PDF]

Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading

Kaitlyn Mary Louise Cramb, Humaira Noor, Iona Thomas-Wright, Maria Claudia Caiazza, Sandor Szunyogh, Ira Milosevic, Dayne Beccano-Kelly, Stephanie J Cragg, and Richard Wade-Martins

bioRxiv posted 13 March 2026 doi:10.64898/2026.03.11.711038

 [Abstract] [PDF]

Brain organization of a memory champion

Roselyne J Chauvin, Annie Zheng, Athanasia Metoki, Samuel R Krimmel, Ashley N Nielsen, Anxu Wang, Philip N Cho, Noah J Baden, Daniel Bower, Kristen M Scheidter, Julia S Monk, Forrest I Whiting, Babatunde Adeyemo, Scott Marek, Benjamin P. Kay, Abraham Z Snyder, Henry L Roediger, Kathleen McDermott, Steven M Nelson, Adrian W Gilmore, Deanna M Barch, Timothy O Laumann, Evan M Gordon, and Nico UF Dosenbach

bioRxiv posted 12 March 2026 doi:10.64898/2026.01.11.698919

 [Abstract] [PDF]