1篇Nature子刊使用了15张同类图！

分享一篇发在Nature Biotechnology上的研究，全文使用大量heatmap，多达十几张，可以学习一番，为自己的CNS吸取美学灵感！

fig1，c, Editing pattern and PreS scores of the five top-performing agRNAs at the endogenous DNMT1 locus using plasmid-based delivery in HEK293T cells (mean of n = 3 independent replicates).

fig1，d, 下侧 NGS plots show the five most frequent edited alleles, with the green-highlighted row indicating the desired allele harboring only the intended A-to-G edit without bystander substitutions (mean of n = 3 independent replicates).

fig2，c, Editing pattern of top enriched ABE-SpRY variants isolated during the PANCE experiment. PreS reflects on-target editing versus bystander editing efficiency (mean of n = 3 independent replicates).

fig2，d,同fig1，d,

fig3，b, Editing efficiencies at the humanDNMT1for ABE ML-predicted single amino acid exchange mutants tested with sgRNACtrl and agRNA56114 in HEK293T cells. c, PreS score of tested variants. Red highlighted residues denote reversions to the wild-type TadA amino acid.

fig3，d、f、j，

fig4，d, Abundance plots display the four most frequent edited alleles, with the green-highlighted row indicating the desired allele containing only the intended A-to-G edit and no bystander substitutions (mean of n = 3 independent replicates).

来源：Perrotta, R.M., Vinke, S., Ferreira, R. et al. Engineered base editors with reduced bystander editing through directed evolution. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02937-w

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