每周的欢喜

1. Naddaf M. (2026). Your brain on drugs: different psychedelics work in surprisingly similar ways. Nature10.1038/d41586-026-01053-2. Advance online publication.

2. Fieldhouse R. (2026). Eye drops made from pig semen deliver cancer treatment to mice. Nature652:284–285.

3. Tian Y, Hornburg K, Austin W, et al.(2026). Magnetic resonance microscopy maps widespread effects of Alzheimer's disease on brain structures and behavior in mice. Nature Neuroscience29:1007–1020.

4. Lee YJ, Lee SJ, Kim JW, et al. (2026). Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. New England Journal of Medicine 394:1365–1375.

5. Mills KT, Krousel-Wood M, Peacock EM, et al.(2026). Multifaceted Strategies for Hypertension Control in Low-Income Patients. New England Journal of Medicine 394:1376–1387.

6. Hadj-MoussaH, UlusanM, HorkaiD, et al. (2026). Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life. bioRxiv 2025.03.27.645766.

7. YagiharaH,  SaitoY,  TakeuchiT, et al. (2026). Fluid amyloid-β (Aβ) biomarkers reflect early β-sheet-rich Aβ deposition during the preclinical stage in Alzheimer’s disease model 5XFAD mice. bioRxiv 2026.04.06.716649.

8. AmorosinoG,  CaronB,  KwonJ, et al. (2026). A retinotopic wiring principle of the human brain.bioRxiv 2026.04.03.716412.

9. N Sommer, A Roumane, M Tiwari, et al. (2026). AAV-mediated delivery of leptin but not adiponectin improves metabolic health in a mouse model of congenital generalised lipodystrophy.bioRxiv 2026.04.07.716869.

10. IiamsSE, SkinnerNJ, Wight-Carter M, et al. (2026). Time-Restricted Feeding Extends Healthspan in Both Sexes and Lifespan in Male C57BL/6J Mice.bioRxiv 2025.10.22.683527.

11. BuratoA,  ClementeAD,  LodettiC, et al. (2026). Prion Protein Deficiency Results in Synaptic, Neural Network and Behavioral Alterations. bioRxiv 2026.04.07.716931.

12. FreiJA, ReidenbachnAG , XunLM, et al.(2026). Phenotypic screening for small molecules that lower PrP in cultured cells. bioRxiv 2026.04.07.716919.

13. Fabian-FineR ,  RomanAG, WeaverAL, et al.(2026). Alzheimer disease: The proposed role of tanycytes in the formation of tau tangles and amyloid beta plaques in human brain. bioRxiv 2025.04.08.647836.

14. CardonaEA ,Webber CJ, Wu Z, et al. (2026). Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a C. elegans model of Alzheimer’s disease. bioRxiv 2025.05.06.652574.

15. Localized active transport shapes the nanoscopic features at the tip of mechanosensory cilia

J Cell Biol April 2026, Vol.225(5), e202412213. doi: 10.1083/jcb.202412213

1、Tissue Regeneration Of mice and frogs

Stella M. Hurtley

Some vertebrates can regenerate limbs, whereas others cannot. By comparing regenerating frog tadpoles and nonregenerating mouse embryonic limbs, Tsissios et al. found that species-specific oxygen sensing determines whether amputation triggers limb regeneration (see the Perspective by Paoli and Whited). Frog tadpoles exhibited reduced oxygen sensing associated with diminished regulation of hypoxia-inducible factor 1A (HIF1A), enabling robust regeneration by promoting biomechanical, epigenetic, and metabolic states conducive to tissue regrowth. By contrast, mouse limbs displayed heightened sensitivity to oxygen, which destabilizes HIF1A and prevents regeneration. Lowering environmental oxygen levels or stabilizing HIF1A allowed mouse limbs to initiate regeneration. Mui et al. used a mouse digit amputation model to investigate why some injuries regenerate while others scar. They found that the extracellular matrix, the network of proteins and sugars surrounding cells, was crucial to regeneration. Regenerating tissue is soft, fluid, and rich in hyaluronic acid, whereas nonregenerating tissue is stiff and collagen heavy. Depleting hyaluronic acid halted regeneration and triggered scarring, whereas stabilizing it improved bone regrowth.

Science p. 176, 10.1126/science.adw8526, p. 177, 10.1126/science.ady3136; see also p. 149, 10.1126/science.aeg3859

DOI: 10.1126/science.ady3136

Tsissios G, Leleu M, Hu K, et al. (2026). Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration. Science392:eadw8526.

Mui BWH, Wong JJY, Dumas CE, et al.  (2026). Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration. Science392:eady3136.

Paoli JC, Whited JL. (2026). Awakening latent regeneration in mammals. Science392:149–150.

 2、Biochemistry

Decoupling Wnt signaling events

Annalisa VanHook

Stabilization of the transcriptional coactivator β-catenin by the morphogen protein Wnt depends on recruitment of the intracellular protein Dishevelled to the Wnt receptor Frizzled, which is thought to depend on Wnt-mediated receptor clustering rather than on conformational changes in Frizzled. Moldaver et al. found that clustering of Frizzled was sufficient for the recruitment and phosphorylation of Dishevelled in human cell lines. The Wnt co-receptor low-density lipoprotein receptor–related protein 5/6 was not necessary for Dishevelled recruitment, but it was necessary to stabilize β-catenin. The finding that Dishevelled recruitment and β-catenin stabilization can be decoupled may shed light on how this process can lead to both β-catenin–dependent and –independent Wnt signaling.

Sci. Signal. (2026) 10.1126/scisignal.aec0204

Moldaver S, Thibeault PE, Robitaille M, et al. (2026). Wnt-dependent Frizzled clustering is required for Dishevelled phosphorylation but insufficient for β-catenin stabilization. ScienceSignaling19:eaec0204.