周末

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3. Huc M, Siddiqi S, Myers M, et al.(2026). Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression. Molecular Psychiatry 31:3674–3682.

4. Adès N, Bouslama-Oueghlani L.(2026).Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain development. Molecular Psychiatry 31:3726–3745. 

5. Abdulkhaliq AA, Alasiri G, Kim B, et al.(2026).TREM2 in neurodegeneration and diseases. Molecular Psychiatry 31:3978–3986. 

6. Mace K, Trang KB, Zimmerman AJ, et al. (2026).Cross-trait clustering of sub-threshold sleep genetic signals identifies EGR2 as a conserved regulator of sleep. bioRxiv 2026.06.12.731887.

7. Abbasi Z, Sadighparvar S, Franquin M, Stellwagen D.(2026).GPCR-mediated regulation of glial TNF production. bioRxiv 2026.06.12.731854.

8. Velasquez E, Savchenko E, Gomez Toledo A.(2026).A convergent metabolic-kinase signaling axis links Parkinson’s disease and multiple system atrophy. bioRxiv 2026.06.11.731777.

9. Wang R, Maloney B, Nho K, et al. (2026).MicroRNA-181 influences Alzheimer’s risk by regulating neprilysin and microtubule-associated tau pathways, offering a novel target. bioRxiv 2026.06.11.731747.

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11. Abdel-Rahman SA, Gabr MT, et al. (2026).AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid Pathology. bioRxiv 2026.06.12.731845.

12. Wakatsuki S, Yumoto A, Suzuki T, Dohmae N, Araki T.(2026). Redox-dependent S-glutathionylation of Aurora-A kinase by Gstp promotes postsynaptic maturation. Journal of Cell Biology 225:e202509200. 

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1. Mohammadi Y, Billig AJ, Berger JI, Griffiths TD. (2026). Brain Representations of Natural Sound Statistics. Journal of Neuroscience 46:e1204252026. 

2. Theisen EK, Rivas-Serna IM, Cheng P, et al. (2026). Lysosomal salvage of neuronal lipids enables glial infiltration of synaptic regions. Neuron 114:2199–2220.e6.

3. Rafii MS. (2026). The Convergence of Down Syndrome and Alzheimer's Disease - Scientific and Ethical Imperatives. New England Journal of Medicine 394:2286–2289. 

4. Chen J, Ogata H, Hikida H.(2026).Genetic manipulation of a giant virus-associated virophage. bioRxiv 2026.06.16.732491.

5. Kranzler CF, Lowenstein DP, Bamshid L, et al. (2026).RNA virus-mediated metabolic reprogramming in a bloom-forming, marine diatom. bioRxiv 2026.06.16.732687.

6. Qi X, Granata A, Van Agtmael T, et al. (2026).HTRA1 deficiency in COL4A1mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel disease. bioRxiv 2026.05.12.724691.

7. Montoye AHK, Curran D, Grosicki GJ. (2026).Who’s been sleeping in my bedroom? Sleep and cardiorespiratory physiology when co-sleeping with a dog, cat, or child. bioRxiv 2026.06.13.732027.

8. Montoye AHK, Curran D, Grosicki GJ. (2026).Erythrocyte Count and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study. bioRxiv 2026.06.08.730977.

9. EADB, EADI, Bonn, ADGC, CHARGE, FinnGen, GERAD, GR@ACE/DEGESCO, & PGC-ALZ(2026).Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias. Nature Genetics 58:1214–1225. 

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11. Gehmacher Q, Kaltenmaier A, Schubert J, et al. (2026).The dynamic relationship between pupil dilation and neural surprise in natural language comprehension. bioRxiv 2026.06.12.731866.

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13. Müller JM, Tobler D, Bühler J, et al. (2026).Continuous Capture of recombinant AAV Particles Using Twin-Column CaptureSMB. bioRxiv 2026.06.12.731701.

14. Brandt M.(2026).Dynamic genetic effects on lifespan. Nature Genetics 58:1200.

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1. Liu Q, Yoo S, Zhang ZA, et al. (2026). Mitochondria-lysosome coupling contributes to lysosome acidification and aging. Molecular Cell 86:2425–2442.e10. 

2. Lu EL, Nay K, Scott JW. (2026). Dangerous liaisons: Promiscuous inhibition of CHK1 and AMPK is a lethal affair for cancer cells. Cell Chemical Biology 33:733–735. 

1. Guo J, Wang P, Liu W, et al. (2026). The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK. Cell Chemical Biology 33:767–784.e7. 

2. Zhu Q, Liu Q, Fan Z, et al. (2026). Optogenetic control of plasma membrane O-GlcNAcylation regulates WNK1 condensates and cellular signaling. Cell Chemical Biology 33:862–876.e8. 

3. Overtus M, Charlick JN, Rubil T, et al. (2026). Correcting mutant CFTR with a stabilizing nanobody reveals a novel active conformation of the channel. bioRxiv 2025.10.08.681081.

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16. Ye X, Qiu X, Urner L, et al. (2026).Antagonists Perturb the MC2R MRAP Complex and Reshape Receptor Conformations. bioRxiv 2026.06.15.731286.

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Cancer Immunology

Attacking tumors by disrupting blood supply

Priscilla N. Kelly

Identification of tumor immunosurveillance and antigen recognition mechanisms is key for the development of improved cancer treatments. Lian et al. studied the tumor microenvironment and found that two immune cell lineages, CD4+ T cells and macrophages, collaborate to cut off the tumors blood supply and kill cancer. CD4+ T cells recognized tumor antigens and triggered macrophages to cluster around intratumoral blood vessels. The T cells released a signal (interleukin-3) that instructed macrophages to produce tumor necrosis factor, which damaged the tumor vasculature and thus impaired the cancer cells’ access to oxygen and nutrients, leading to widespread tumor cell death. This mechanism suggests an approach to attack tumors by disrupting their supporting environment rather than killing the tumor cells directly.

Science p. 1256, 10.1126/science.ads7910

Lian Q, Nie J, Singh J, et al.(2026). CD4⁺T cells impair tumor growth through IL-3 and TNF-dependent vascular damage. Science 392:eads7910. 

Molecular Biology

Protein-templated DNA synthesis

Di Jiang

Bacterial defense systems often deploy unconventional biochemistry to thwart viral infection. Investigating the antiphage system DRT3, Deng et al. found that it defends against infection by synthesizing repetitive poly(GT/AC) double-stranded DNA using two distinct reverse transcriptases (RTs). One of its RTs copies a noncoding RNA, and the second synthesizes the complementary DNA strand de novo without any nucleic acid template. Instead, it uses its own amino acids as a physical mold to enforce precise base alternation. This work reveals a surprising protein-templated mechanism for sequence-specific DNA synthesis, expanding the known repertoire of enzymatic polymerization.

Science p. 1274, 10.1126/science.aed1656

Deng P, Lee H, Armijo C, Wang H, Gao A. (2026). Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase. Science 392:1274–1281. 

Neurophysiology

Catching the (brain) waves

Mattia Maroso

Waves of brain activity (traveling waves) have been observed in many species. Given their prevalence and magnitude, it has been hypothesized that these waves likely play an important role in the brain. However, their functions remain to be elucidated. Ye et al. used wide-field calcium imaging to study traveling waves in the mouse neocortex. Traveling waves coincided with the recruitment of spiking activity in connected subcortical structures and were well coordinated between the two hemispheres. The arrangement of local axons in the sensory cortex followed the shape of the traveling waves. These results open new avenues of inquiry into the mechanisms underlying traveling waves and their function.

Science p. 1260, 10.1126/science.adx1369

Ye Z, Ladd AE, MacKenzie N, et al. (2026). Brain-wide topographic coordination of rotating waves. Science 392:eadx1369. 

GPCR Signaling

Deorphanizing an adipocyte GPCR

John F. Foley

GPRC5B is an orphan G protein–coupled receptor (GPCR) found on adipocytes. GPRC5B-deficient mice are resistant to high-fat diet–induced obesity and have reduced adipose inflammation. Using a virion-based GPCR expression system combined with human protein microarrays, Johansen et al. identified the macrophage glycoprotein MD-1 as a potential endogenous GPRC5B agonist. Biochemical and functional assays showed that MD-1 stimulated Gαs-dependent signaling through GPRC5B, and cell-cell contact experiments between macrophage and adipocyte cell lines in vitro showed that MD-1 stimulated lipolysis in adipocytes, suggesting that this pathway should be investigated for therapeutic potential in obesity.

Sci. Signal. (2026) 10.1126/scisignal.adr8554

Johansen E, Syu GD, Wan Z, et al. (2026). Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B. Science Signaling 19:eadr8554.